Simparica Trio (Sarolaner / Moxidectin / Pyrantel) Dosage for Dogs

Antiparasitic combination ⏱ Onset: 4-8 hours (fleas) ⏳ Duration: 30 days

This dosage information is for educational purposes only. Always consult your veterinarian before giving any medication to your pet. Dosages may vary based on your pet's health conditions, other medications, and individual factors.

Dosage Calculator

Enter your dog's weight to calculate the recommended dose.

Your dog's weight

Simparica Trio Dosage Chart for Dogs by Weight

Scroll sideways to see full table

Weight	Low Dose	Standard Dose	Max Dose	Frequency
5 lbs (2.3 kg)	3mg (3mg tablet)	3mg (3mg tablet)	5.5mg (2 × 3mg)	once monthly
10 lbs (4.5 kg)	5.5mg (2 × 3mg)	5.5mg (2 × 3mg)	11mg	once monthly
15 lbs (6.8 kg)	8mg	8mg	16.5mg	once monthly
20 lbs (9.1 kg)	11mg	11mg	22mg	once monthly
25 lbs (11.3 kg)	13.5mg	13.5mg	27mg (9 × 3mg)	once monthly
30 lbs (13.6 kg)	16.5mg	16.5mg	32.5mg (11 × 3mg)	once monthly
40 lbs (18.1 kg)	21.5mg (7 × 3mg)	21.5mg (7 × 3mg)	43.5mg	once monthly
50 lbs (22.7 kg)	27mg (9 × 3mg)	27mg (9 × 3mg)	54.5mg (18 × 3mg)	once monthly
60 lbs (27.2 kg)	32.5mg (11 × 3mg)	32.5mg (11 × 3mg)	65.5mg (22 × 3mg)	once monthly
70 lbs (31.7 kg)	38mg	38mg	76mg	once monthly
80 lbs (36.3 kg)	43.5mg	43.5mg	87mg (29 × 3mg)	once monthly
90 lbs (40.8 kg)	49mg	49mg	98mg	once monthly
100 lbs (45.4 kg)	54.5mg (18 × 3mg)	54.5mg (18 × 3mg)	109mg	once monthly
120 lbs (54.4 kg)	65.5mg (22 × 3mg)	65.5mg (22 × 3mg)	130.5mg	once monthly
150 lbs (68 kg)	81.5mg (27 × 3mg)	81.5mg (27 × 3mg)	163mg	once monthly

What is Simparica Trio (Sarolaner / Moxidectin / Pyrantel) used for in dogs?

flea prevention tick prevention heartworm prevention roundworm treatment hookworm treatment

How to give Simparica Trio to your dog

Simparica Trio is a flavored chewable tablet given once monthly. Give with food for best absorption. Give on the same date each month for consistent protection. A heartworm test is required before starting. Do not split or break the tablet — use the size prescribed for your dog's weight range.

Available Forms

chewable tablet

Give with Food?

Yes — give with food

Side effects of Simparica Trio in dogs

Common side effects

vomiting

diarrhea

lethargy

decreased appetite

Serious side effects

seizures (rare, in dogs with seizure history)
tremors
ataxia
severe allergic reaction

When to call the vet

Call your vet immediately if your dog shows any of these signs:

Seizures or tremors after dosing
Persistent vomiting or diarrhea
Severe lethargy or weakness
Signs of allergic reaction (facial swelling, hives)
Your dog did not eat the full tablet

Frequently Asked Questions

What does Simparica Trio protect against?

Simparica Trio is an all-in-one monthly chewable that protects against 5 types of ticks, fleas, heartworm disease, roundworms, and hookworms. It is one of the most comprehensive single-tablet parasite preventions available for dogs.

Is Simparica Trio safe for dogs?

Simparica Trio is FDA-approved and considered safe for most dogs 8 weeks and older weighing at least 2.8 lbs. However, isoxazoline products (including sarolaner) have been associated with rare neurological events (tremors, seizures) in some dogs. Use with caution in dogs with a history of seizures.

Can I give Simparica Trio without a heartworm test?

No. A heartworm test is required before starting Simparica Trio. Giving heartworm preventives to a dog already infected with adult heartworms can cause serious, potentially fatal reactions. Your vet will test your dog before prescribing.

What if my dog vomits after taking Simparica Trio?

If your dog vomits within 2 hours of taking Simparica Trio, the medication may not have been fully absorbed. Contact your vet — they may recommend giving another full dose. If vomiting occurs after 2 hours, the medication has likely been absorbed sufficiently.