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PetDosageChart

Serotonin (5-HT3) receptor antagonist antiemetic · For Dogs · 80 lb

How much Zofran for a 80 lb dog?

A 80 lb dog (36.3 kg) should receive approximately 27.2 mg of Zofran per dose, given Every 8-12 hours.

This dosage information is for educational purposes only. Always consult your veterinarian before giving any medication to your pet. Dosages may vary based on your pet's health conditions, other medications, and individual factors.

Content reviewed by licensed veterinarians. Sourced from Plumb's Veterinary Drug Handbook and the Merck Veterinary Manual.

Dosage · 80 lb dog

Zofran dose for a 80 lb dog

Low Dose

18.1

mg

Standard

27.2

mg

Max Safe

36.3

mg

Frequency

Every 8-12 hours

Weight in kg

36.3 kg

Always confirm with your veterinarian before administering medication. These calculations are estimates based on published veterinary pharmacology references.

Other Weights

Zofran for a different size dog

FAQ · 80 lb dog

Questions about Zofran for a 80 lb dog

How much Zofran for a 80 lb dog?
A 80 lb dog should receive approximately 27.2 mg of Zofran (Ondansetron) per dose, given Every 8-12 hours. That works out to about 6.75 × 4 mg. Always confirm with your veterinarian before administering medication.
What is the safe dose range of Zofran for a 80 lb dog?
The published dose range for a 80 lb dog is roughly 18.1 mg (low) to 36.3 mg (max safe), with 27.2 mg as the typical standard dose. Frequency: Every 8-12 hours.
How often can I give Zofran to a 80 lb dog?
Zofran is typically given Every 8-12 hours. Do not exceed the recommended frequency without veterinary guidance.

Need a different weight?

Use the calculator on the main Zofran page for any exact weight, or read the full dosage chart and safety information.

Full Zofran dosage guide →

Sources · 09

Sources & references

The dosage information on this page is compiled from the following veterinary and pharmaceutical references:

  • Plumb's Veterinary Drug Handbook — the standard veterinary pharmacology reference used by veterinarians worldwide.
  • Merck Veterinary Manual — a trusted, peer-reviewed resource for veterinary professionals and pet owners.
  • DailyMed (FDA Drug Labels) — official FDA-approved drug labeling and prescribing information for Ondansetron.

Read more about our methodology and how we calculate dosages.