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PetDosageChart

Antiparasitic combination · For Dogs · 100 lb

How much Simparica Trio for a 100 lb dog?

A 100 lb dog (45.4 kg) should receive approximately 54.4 mg of Simparica Trio per dose, given once monthly.

This dosage information is for educational purposes only. Always consult your veterinarian before giving any medication to your pet. Dosages may vary based on your pet's health conditions, other medications, and individual factors.

Content reviewed by licensed veterinarians. Sourced from Plumb's Veterinary Drug Handbook and the Merck Veterinary Manual.

Dosage · 100 lb dog

Simparica Trio dose for a 100 lb dog

Low Dose

54.4

mg

Standard

54.4

mg

Max Safe

108.8

mg

Frequency

once monthly

Weight in kg

45.4 kg

Always confirm with your veterinarian before administering medication. These calculations are estimates based on published veterinary pharmacology references.

Other Weights

Simparica Trio for a different size dog

FAQ · 100 lb dog

Questions about Simparica Trio for a 100 lb dog

How much Simparica Trio for a 100 lb dog?
A 100 lb dog should receive approximately 54.4 mg of Simparica Trio (Sarolaner / Moxidectin / Pyrantel) per dose, given once monthly. That works out to about 18.25 × 3 mg. Always confirm with your veterinarian before administering medication.
What is the safe dose range of Simparica Trio for a 100 lb dog?
The published dose range for a 100 lb dog is roughly 54.4 mg (low) to 108.8 mg (max safe), with 54.4 mg as the typical standard dose. Frequency: once monthly.
How often can I give Simparica Trio to a 100 lb dog?
Simparica Trio is typically given once monthly. Do not exceed the recommended frequency without veterinary guidance.

Need a different weight?

Use the calculator on the main Simparica Trio page for any exact weight, or read the full dosage chart and safety information.

Full Simparica Trio dosage guide →

Sources · 09

Sources & references

The dosage information on this page is compiled from the following veterinary and pharmaceutical references:

  • Plumb's Veterinary Drug Handbook — the standard veterinary pharmacology reference used by veterinarians worldwide.
  • Merck Veterinary Manual — a trusted, peer-reviewed resource for veterinary professionals and pet owners.
  • DailyMed (FDA Drug Labels) — official FDA-approved drug labeling and prescribing information for Sarolaner / Moxidectin / Pyrantel.

Read more about our methodology and how we calculate dosages.