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PetDosageChart

Antibiotic (Penicillin) · For Dogs

How much Amoxicillin (Amoxil) can I give my dog?

Standard Amoxicillin dose for dogs is 10 mg per kg (4.54 mg per lb), given every 8-12 hours. Use the calculator below for your dog's exact weight, or jump to the weight-by-weight chart.

Onset
1-2 hours
Duration
8-12 hours
Class
Antibiotic (Penicillin)

Calculator estimate from Plumb’s Veterinary Drug Handbook. Not yet vet-reviewed — see our methodology .

This dosage information is for educational purposes only. Always consult your veterinarian before giving any medication to your pet. Dosages may vary based on your pet's health conditions, other medications, and individual factors.

Content reviewed by licensed veterinarians. Sourced from Plumb's Veterinary Drug Handbook and the Merck Veterinary Manual.

Dosage Calculator · 01

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By Weight

Amoxil dose by dog weight

Pick your dog's weight to jump to a dedicated page with the dose, frequency, safety notes, and FAQ for that size.

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Dosage Chart · 02

Amoxil dosage for dogs by weight

Scroll sideways to see full table

Weight Low Dose Standard Max Safe Frequency
5 lbs (2.3 kg) 11.5mg 23mg 57.5mg (50mg tablet) every 8-12 hours
10 lbs (4.5 kg) 22.5mg 45mg (50mg tablet) 112.5mg every 8-12 hours
15 lbs (6.8 kg) 34mg 68mg 170mg every 8-12 hours
20 lbs (9.1 kg) 45.5mg (50mg tablet) 91mg (2 × 50mg) 227.5mg every 8-12 hours
25 lbs (11.3 kg) 56.5mg (50mg tablet) 113mg 282.5mg every 8-12 hours
30 lbs (13.6 kg) 68mg 136mg 340mg (7 × 50mg) every 8-12 hours
40 lbs (18.1 kg) 90.5mg (2 × 50mg) 181mg 452.5mg (9 × 50mg) every 8-12 hours
50 lbs (22.7 kg) 113.5mg 227mg 567.5mg every 8-12 hours
60 lbs (27.2 kg) 136mg 272mg 680mg every 8-12 hours
70 lbs (31.7 kg) 158.5mg (3 × 50mg) 317mg 792.5mg (16 × 50mg) every 8-12 hours
80 lbs (36.3 kg) 181.5mg 363mg 907.5mg (18 × 50mg) every 8-12 hours
90 lbs (40.8 kg) 204mg (4 × 50mg) 408mg (8 × 50mg) 1020mg every 8-12 hours
100 lbs (45.4 kg) 227mg 454mg (9 × 50mg) 1135mg every 8-12 hours
120 lbs (54.4 kg) 272mg 544mg (11 × 50mg) 1360mg (27 × 50mg) every 8-12 hours
150 lbs (68 kg) 340mg (7 × 50mg) 680mg 1700mg (34 × 50mg) every 8-12 hours

Common Uses · 03

What is Amoxil (Amoxicillin) used for in dogs?

bacterial infections skin infections urinary tract infections respiratory infections dental infections

Administration · 04

How to give Amoxil to your dog

Amoxicillin can be given with or without food, but giving with food may reduce stomach upset. Always complete the full course of antibiotics as prescribed, even if your dog appears to feel better before the medication is finished. Stopping early can lead to antibiotic resistance.

Available Forms

tablet, capsule, liquid suspension

Give with Food?

Yes — give with food

Side Effects · 05

Side effects of Amoxil in dogs

Common side effects

diarrhea
nausea
vomiting
decreased appetite

Serious side effects — call your vet

  • allergic reaction (facial swelling, hives)
  • severe diarrhea
  • difficulty breathing
  • seizures (rare, at very high doses)

Emergency · 06

When to call the vet

Call your vet immediately if your dog shows any of these signs:

  • Signs of allergic reaction (facial swelling, hives, difficulty breathing)
  • Severe or bloody diarrhea
  • Vomiting persists after multiple doses
  • No improvement after 48-72 hours of treatment
  • Rash or skin irritation develops

For Cats

Looking for Amoxicillin dosage for cats?

View the Amoxicillin dosage chart and calculator for cats.

Related · 08

Related medications for dogs

Sources · 09

Sources & references

The dosage information on this page is compiled from the following veterinary and pharmaceutical references:

  • Plumb's Veterinary Drug Handbook — the standard veterinary pharmacology reference used by veterinarians worldwide.
  • Merck Veterinary Manual — a trusted, peer-reviewed resource for veterinary professionals and pet owners.
  • DailyMed (FDA Drug Labels) — official FDA-approved drug labeling and prescribing information for Amoxicillin.

Read more about our methodology and how we calculate dosages.

Transparency · 11

How this page was made

Sourced from Plumb's Veterinary Drug Handbook, the reference used in US vet schools. Every dose, frequency, and tablet count on this page is generated from that data, then checked against the published references below.

Sources cited
  • Plumb's Veterinary Drug Handbook
  • Merck Veterinary Manual
Calculator formula
Doses scale linearly from a standard basis of 10 mg per kg (4.54 mg per lb) of body weight, given every 8-12 hours. The calculator multiplies that basis by your dog's weight and rounds to the closest available tablet size.
Last-reviewed status
Automated from Plumb’s, not yet vet-reviewed.

More on our methodology and editorial process — how we source, calculate, and review dogs dosage data.

Frequently Asked · 07

Questions about this medication

Can I give my dog human amoxicillin?
While the active ingredient is the same, you should only give your dog amoxicillin prescribed by a veterinarian. Human formulations may contain different doses or inactive ingredients. Your vet needs to determine the correct dose and duration based on the type and severity of infection.
How much amoxicillin do I give my dog?
The typical dose is 5-10 mg per kilogram of body weight, given every 8-12 hours. For more serious infections, your vet may prescribe up to 25 mg/kg. The dose depends on the type and severity of infection, so always follow your vet's prescription.
How long does amoxicillin take to work in dogs?
Amoxicillin begins fighting bacteria within 1-2 hours, but visible improvement in symptoms usually takes 2-3 days. It's crucial to complete the entire prescribed course (typically 7-14 days) even if your dog seems better, to fully eliminate the infection and prevent resistance.
What are the side effects of amoxicillin in dogs?
The most common side effects are gastrointestinal, including diarrhea, nausea, and vomiting. These are usually mild. Serious allergic reactions (facial swelling, difficulty breathing) are rare but require immediate emergency care. Probiotics may help reduce digestive side effects.

Safety · 10

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