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PetDosageChart

Galliprant (Grapiprant) Dosage for Dogs

Prostaglandin receptor antagonist (piprant) ⏱ Onset: 1-2 hours ⏳ Duration: 24 hours

This dosage information is for educational purposes only. Always consult your veterinarian before giving any medication to your pet. Dosages may vary based on your pet's health conditions, other medications, and individual factors.

Content reviewed by licensed veterinarians. This information is sourced from veterinary drug references including Plumb's Veterinary Drug Handbook and the Merck Veterinary Manual.

Dosage Calculator

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Galliprant Dosage Chart for Dogs by Weight

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Weight Low Dose Standard Dose Max Dose Frequency
5 lbs (2.3 kg) 4.5mg 4.5mg 4.5mg once daily
10 lbs (4.5 kg) 9mg 9mg 9mg once daily
15 lbs (6.8 kg) 13.5mg 13.5mg 13.5mg once daily
20 lbs (9.1 kg) 18mg (20mg tablet) 18mg (20mg tablet) 18mg (20mg tablet) once daily
25 lbs (11.3 kg) 22.5mg (20mg tablet) 22.5mg (20mg tablet) 22.5mg (20mg tablet) once daily
30 lbs (13.6 kg) 27mg 27mg 27mg once daily
40 lbs (18.1 kg) 36mg (2 × 20mg) 36mg (2 × 20mg) 36mg (2 × 20mg) once daily
50 lbs (22.7 kg) 45.5mg 45.5mg 45.5mg once daily
60 lbs (27.2 kg) 54.5mg 54.5mg 54.5mg once daily
70 lbs (31.7 kg) 63.5mg (3 × 20mg) 63.5mg (3 × 20mg) 63.5mg (3 × 20mg) once daily
80 lbs (36.3 kg) 72.5mg 72.5mg 72.5mg once daily
90 lbs (40.8 kg) 81.5mg (4 × 20mg) 81.5mg (4 × 20mg) 81.5mg (4 × 20mg) once daily
100 lbs (45.4 kg) 91mg 91mg 91mg once daily
120 lbs (54.4 kg) 109mg 109mg 109mg once daily
150 lbs (68 kg) 136mg (7 × 20mg) 136mg (7 × 20mg) 136mg (7 × 20mg) once daily

What is Galliprant (Grapiprant) used for in dogs?

osteoarthritis pain joint inflammation

How to give Galliprant to your dog

Galliprant is best given on an empty stomach for optimal absorption, but it can be given with food if it causes stomach upset. It is a flavored tablet. Do not combine with other anti-inflammatory drugs (NSAIDs or steroids). Galliprant is considered gentler on the GI tract and kidneys than traditional NSAIDs.

Available Forms

tablet

Give with Food?

No — can be given without food

Side effects of Galliprant in dogs

Common side effects

vomiting
diarrhea
soft stool
decreased appetite

Serious side effects

  • gastrointestinal ulceration (less risk than traditional NSAIDs)
  • liver enzyme elevation
  • kidney effects
  • protein loss in urine

When to call the vet

Call your vet immediately if your dog shows any of these signs:

  • Vomiting or bloody stool
  • Loss of appetite for more than 24 hours
  • Increased thirst or urination
  • Lethargy or depression
  • No pain relief after 1-2 weeks of use

Related Medications for Dogs

H2 receptor antagonist

Pepcid

Famotidine

For stomach acid reduction

View dosage chart
NK1 receptor antagonist / Antiemetic

Cerenia

Maropitant

For vomiting

View dosage chart
Serotonin (5-HT3) receptor antagonist antiemetic

Zofran

Ondansetron

For Nausea and vomiting

View dosage chart
Serotonin antagonist and reuptake inhibitor (SARI)

Desyrel

Trazodone

For anxiety

View dosage chart

Sources & References

The dosage information on this page is compiled from the following veterinary and pharmaceutical references:

  • Plumb's Veterinary Drug Handbook — the standard veterinary pharmacology reference used by veterinarians worldwide.
  • Merck Veterinary Manual — a trusted, peer-reviewed resource for veterinary professionals and pet owners.
  • DailyMed (FDA Drug Labels) — official FDA-approved drug labeling and prescribing information for Grapiprant.

Frequently Asked Questions

Is Galliprant better than Rimadyl for dogs?
Galliprant works differently from traditional NSAIDs like Rimadyl (carprofen). As a piprant, it specifically targets the EP4 receptor involved in osteoarthritis pain, potentially causing fewer GI and kidney side effects. However, traditional NSAIDs may provide stronger anti-inflammatory effects. Your vet will recommend the best option for your dog.
Can Galliprant be used long-term?
Yes, Galliprant is approved for long-term daily use in dogs with osteoarthritis. It is designed to be a safer option for chronic pain management compared to traditional NSAIDs. Regular veterinary checkups and blood work are still recommended.
How much does Galliprant cost?
Galliprant is generally more expensive than generic NSAIDs like carprofen. The cost varies by dog weight and pharmacy but typically ranges from $50-100+ per month. Some pet insurance plans and pharmacy discount programs can help reduce the cost.
Does Galliprant make dogs drowsy?
Drowsiness is not a common side effect of Galliprant. Unlike some pain medications, Galliprant does not cause sedation. If your dog seems more tired or lethargic after starting Galliprant, it could indicate a side effect that should be discussed with your vet.

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