Prostaglandin receptor antagonist (piprant) · For Dogs

Galliprant dosage reference for dogs (Grapiprant)

This page's standard weight-based reference is 2 mg per kg (0.91 mg per lb), with once daily recorded as the reference frequency. Use the calculator to see the arithmetic for your dog's weight, then confirm the indication, product, and actual dose with a veterinarian.

Onset: 1-2 hours
Duration: 24 hours
Class: Prostaglandin receptor antagonist (piprant)

Weight-based calculator estimate from the references listed on this page. This page has not been independently DVM-reviewed — see our methodology .

This information is for educational purposes only. Always consult your veterinarian before giving medication to your pet. Do not use this calculator for emergencies, overdoses, pregnancy, very young animals, very old animals, pets with liver/kidney disease, or pets taking multiple medications.

Each medication page lists the references recorded for its data. The calculator math and editorial presentation are maintained by PetDosageChart; a page is independently DVM-reviewed only when a named reviewer byline appears. See our methodology and limitations.

Grapiprant (often known by brand names such as Galliprant) is a prostaglandin receptor antagonist (piprant) commonly used in veterinary medicine for osteoarthritis pain and joint inflammation. Understanding the correct dosage, administration, and potential side effects of Grapiprant is critical for your dog’s safety and well-being.

A typical Grapiprant dose for dogs is around 2 mg/kg once daily. Available forms include tablet.

Calculator Warning: Use this only as an educational estimate. Your veterinarian may prescribe a different dose based on your pet’s condition, age, weight, other medications, and medical history.

Grapiprant Dosage Calculator for Dogs

Enter your dog’s weight below to estimate the Grapiprant dose from the 2 mg/kg guideline. Your veterinarian may adjust it for your dog’s age, condition, and other medications, so treat the result as an educational starting point, not a prescription.

Dosage Calculator · 01

Enter your dog's weight

Quick Dosage Chart

Typical Grapiprant amounts for common dog weights, for quick reference:

Dosage Chart · 02

Galliprant weight-based reference chart for dogs

Scroll sideways to see full table

Weight	Lower Reference	Standard Reference	Upper Reference	Frequency
5 lbs (2.3 kg)	4.6 mg	4.6 mg	4.6 mg	once daily
10 lbs (4.5 kg)	9.0 mg	9.0 mg	9.0 mg	once daily
15 lbs (6.8 kg)	13.6 mg	13.6 mg	13.6 mg	once daily
20 lbs (9.1 kg)	18.2 mg (20mg tablet)	18.2 mg (20mg tablet)	18.2 mg (20mg tablet)	once daily
25 lbs (11.3 kg)	22.6 mg (20mg tablet)	22.6 mg (20mg tablet)	22.6 mg (20mg tablet)	once daily
30 lbs (13.6 kg)	27.2 mg	27.2 mg	27.2 mg	once daily
40 lbs (18.1 kg)	36.2 mg (2 × 20mg)	36.2 mg (2 × 20mg)	36.2 mg (2 × 20mg)	once daily
50 lbs (22.7 kg)	45.4 mg	45.4 mg	45.4 mg	once daily
60 lbs (27.2 kg)	54.4 mg	54.4 mg	54.4 mg	once daily
70 lbs (31.7 kg)	63.4 mg (3 × 20mg)	63.4 mg (3 × 20mg)	63.4 mg (3 × 20mg)	once daily
80 lbs (36.3 kg)	72.6 mg	72.6 mg	72.6 mg	once daily
90 lbs (40.8 kg)	81.6 mg (4 × 20mg)	81.6 mg (4 × 20mg)	81.6 mg (4 × 20mg)	once daily
100 lbs (45.4 kg)	90.8 mg	90.8 mg	90.8 mg	once daily
120 lbs (54.4 kg)	108.8 mg	108.8 mg	108.8 mg	once daily
150 lbs (68 kg)	136.0 mg (7 × 20mg)	136.0 mg (7 × 20mg)	136.0 mg (7 × 20mg)	once daily

Parenthetical tablet amounts are arithmetic comparisons only. They do not account for scoring, release type, concentration, product labeling, or whether this medication is appropriate for an individual animal.

By Weight

Galliprant reference by dog weight

Choose a common weight to open its optional reference page. Use the main medication calculator for a different exact weight.

Common-weight pages are convenience views of the same educational reference, not separate medical recommendations.

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How to Give Grapiprant to Your Dog

Galliprant is best given on an empty stomach for optimal absorption, but it can be given with food if it causes stomach upset. It is a flavored tablet. Do not combine with other anti-inflammatory drugs (NSAIDs or steroids). Galliprant is considered gentler on the GI tract and kidneys than traditional NSAIDs.

It may interact with other NSAIDs, corticosteroids, protein-bound drugs, and ACE inhibitors.

Side Effects and Safety

Common side effects include vomiting, diarrhea, soft stool, and decreased appetite. More serious side effects can occur, such as gastrointestinal ulceration (less risk than traditional NSAIDs), liver enzyme elevation, kidney effects, and protein loss in urine.

Cautions · 12

When Galliprant should be used with caution or avoided

Some dogs should not take Galliprant, or need a different dose and closer monitoring. Tell your veterinarian about your pet's full health history and every other medication or supplement they take before giving Galliprant.

dogs under 8 months or under 8 lbs
use with other NSAIDs or corticosteroids
severe liver or kidney disease

Interactions · 13

Galliprant drug interactions

Galliprant can interact with other drugs. This list is not complete — always give your veterinarian a full list of your dog's medications and supplements.

other NSAIDs

corticosteroids

protein-bound drugs

ACE inhibitors

Calculator Limits · 14

When not to use this calculator

This calculator gives a general educational estimate for a healthy adult dog at a known weight. Do not rely on it in these situations — talk to your veterinarian instead:

In an emergency, or after accidental ingestion or a suspected overdose
For pregnant or nursing pets
For very young or very old dogs
For pets with liver disease, kidney disease, or another chronic illness
For pets taking several medications at once
When you are not sure of your dog's current, accurate weight
For combination products that contain additional active ingredients

Overdose · 15

Suspected overdose: what to do

If you think your dog had too much Galliprant, or swallowed any medication by accident, act right away. Do not wait for symptoms to appear.

Call your veterinarian or the nearest emergency animal hospital.
ASPCA Animal Poison Control Center: (888) 426-4435
Pet Poison Helpline: (855) 764-7661

A consultation fee may apply to the poison hotlines. Have the medication packaging ready, and note how much your pet may have taken and when. Do not try to make your pet vomit unless a veterinarian tells you to.

When to Call the Vet

If your dog experiences any of the following, contact your veterinarian or an emergency clinic immediately:

Vomiting or bloody stool
Loss of appetite for more than 24 hours
Increased thirst or urination
Lethargy or depression
No pain relief after 1-2 weeks of use

Frequently Asked Questions

Frequently Asked · 07

Questions about this medication

Is Galliprant better than Rimadyl for dogs?

Galliprant works differently from traditional NSAIDs like Rimadyl (carprofen). As a piprant, it specifically targets the EP4 receptor involved in osteoarthritis pain, potentially causing fewer GI and kidney side effects. However, traditional NSAIDs may provide stronger anti-inflammatory effects. Your vet will recommend the best option for your dog.

Can Galliprant be used long-term?

Yes, Galliprant is approved for long-term daily use in dogs with osteoarthritis. It is designed to be a safer option for chronic pain management compared to traditional NSAIDs. Regular veterinary checkups and blood work are still recommended.

How much does Galliprant cost?

Galliprant is generally more expensive than generic NSAIDs like carprofen. The cost varies by dog weight and pharmacy but typically ranges from $50-100+ per month. Some pet insurance plans and pharmacy discount programs can help reduce the cost.

Does Galliprant make dogs drowsy?

Drowsiness is not a common side effect of Galliprant. Unlike some pain medications, Galliprant does not cause sedation. If your dog seems more tired or lethargic after starting Galliprant, it could indicate a side effect that should be discussed with your vet.

Use This Guide Safely · 08

What weight alone cannot tell you

The calculator performs one narrow job: it multiplies your dog's weight by the lower, standard, and upper mg/kg values recorded for Galliprant. It cannot decide whether this drug, indication, formulation, or schedule is appropriate for an individual animal.

Context in this medication record

Commonly listed uses: osteoarthritis pain, joint inflammation
Recorded forms: tablet
Reference timing: once daily; onset 1-2 hours; duration 24 hours

Individual checks a calculator cannot perform

Confirm the diagnosis and the reason this medication is being considered.
Match the exact product, concentration, route, and whether a tablet may be split.
Account for age, pregnancy, organ function, genetics, allergies, and prior reactions.
Review every prescription, over-the-counter product, and supplement your pet takes.

Recorded cautions

dogs under 8 months or under 8 lbs; use with other NSAIDs or corticosteroids; severe liver or kidney disease.

Recorded interactions

other NSAIDs; corticosteroids; protein-bound drugs; ACE inhibitors.

These lists reproduce the structured record used by this page and may not be exhaustive. Show your veterinarian the product label and your dog's complete medication list before acting on a number.

Related · 08

Related medications for dogs

Sources · 09

Sources & references

The structured medication record behind this page names the references below. The links open the publisher or official resource; they do not turn this page into a prescription for an individual animal.

Plumb's Veterinary Drug Handbook — listed in this medication's source record.
Merck Veterinary Manual — listed in this medication's source record.
DailyMed label search for Grapiprant — check current product and formulation labels; some veterinary uses may be off-label.

Source names are shown at the record level; passage-level page and label citations are still being added. Read our methodology and limitations.

Transparency · 11

How this page was made

This page's structured medication record includes Plumb's Veterinary Drug Handbook among its source names. PetDosageChart applies the record's mg/kg values to the entered weight and presents the arithmetic result. A source record is not the same as an individualized prescription or an independent clinical review.

Sources cited: Plumb's Veterinary Drug Handbook
Merck Veterinary Manual
Calculator formula: Doses scale linearly from a standard basis of 2 mg per kg (0.91 mg per lb) of body weight, given once daily. The calculator multiplies that basis by your dog's weight and shows an arithmetic comparison with recorded tablet sizes. That comparison does not determine whether a tablet is scored, splittable, or appropriate for your pet.
Editorial owner: Prepared and maintained by the PetDosageChart editorial team, a software-led publisher and not a veterinary practice.
DVM review status: Not independently DVM-reviewed. A named reviewer and review date appear here only after a confirmed review.

More on our methodology and editorial process — how we source, calculate, and review dogs dosage data.

Safety · 10

More resources

Pet Medication Safety Hub — What's safe, what's dangerous, and emergency signs
How we calculate dosages — Our sources, math, and review process
Printable emergency checklist — One-page reference for your fridge or first aid kit