Anticonvulsant · For Dogs
Keppra dosage reference for dogs (Levetiracetam)
This page's standard weight-based reference is 40 mg per kg (18.14 mg per lb), with Every 8 hours recorded as the reference frequency. Use the calculator to see the arithmetic for your dog's weight, then confirm the indication, product, and actual dose with a veterinarian.
- Onset
- 1-2 hours
- Duration
- 8 hours (immediate release)
- Class
- Anticonvulsant
Weight-based calculator estimate from the references listed on this page. This page has not been independently DVM-reviewed — see our methodology .
This information is for educational purposes only. Always consult your veterinarian before giving medication to your pet. Do not use this calculator for emergencies, overdoses, pregnancy, very young animals, very old animals, pets with liver/kidney disease, or pets taking multiple medications.
Each medication page lists the references recorded for its data. The calculator math and editorial presentation are maintained by PetDosageChart; a page is independently DVM-reviewed only when a named reviewer byline appears. See our methodology and limitations.
Levetiracetam (often known by brand names such as Keppra) is an anticonvulsant commonly used in veterinary medicine for Epilepsy, Seizure management, Cluster seizures, Status epilepticus (emergency), and Add-on seizure therapy. Understanding the correct dosage, administration, and potential side effects of Levetiracetam is critical for your dog’s safety and well-being.
A typical Levetiracetam dose for dogs is around 40 mg/kg Every 8 hours, within a usual range of 20-60 mg/kg. Available forms include Tablet, Extended-release tablet, Oral solution, and Injectable.
Calculator Warning: Use this only as an educational estimate. Your veterinarian may prescribe a different dose based on your pet’s condition, age, weight, other medications, and medical history.
Levetiracetam Dosage Calculator for Dogs
Enter your dog’s weight below to estimate the Levetiracetam dose from the 40 mg/kg guideline. Your veterinarian may adjust it for your dog’s age, condition, and other medications, so treat the result as an educational starting point, not a prescription.
Dosage Calculator · 01
Enter your dog's weight
Quick Dosage Chart
Typical Levetiracetam amounts for common dog weights, for quick reference:
Dosage Chart · 02
Keppra weight-based reference chart for dogs
Scroll sideways to see full table
| Weight | Lower Reference | Standard Reference | Upper Reference | Frequency |
|---|---|---|---|---|
| 5 lbs (2.3 kg) | 46.0 mg | 92.0 mg | 138.0 mg | Every 8 hours |
| 10 lbs (4.5 kg) | 90.0 mg | 180.0 mg | 270.0 mg (250mg tablet) | Every 8 hours |
| 15 lbs (6.8 kg) | 136.0 mg | 272.0 mg (250mg tablet) | 408.0 mg | Every 8 hours |
| 20 lbs (9.1 kg) | 182.0 mg | 364.0 mg | 546.0 mg (2 × 250mg) | Every 8 hours |
| 25 lbs (11.3 kg) | 226.0 mg (250mg tablet) | 452.0 mg (2 × 250mg) | 678.0 mg | Every 8 hours |
| 30 lbs (13.6 kg) | 272.0 mg (250mg tablet) | 544.0 mg (2 × 250mg) | 816.0 mg | Every 8 hours |
| 40 lbs (18.1 kg) | 362.0 mg | 724.0 mg (3 × 250mg) | 1086.0 mg | Every 8 hours |
| 50 lbs (22.7 kg) | 454.0 mg (2 × 250mg) | 908.0 mg | 1362.0 mg | Every 8 hours |
| 60 lbs (27.2 kg) | 544.0 mg (2 × 250mg) | 1088.0 mg | 1632.0 mg | Every 8 hours |
| 70 lbs (31.7 kg) | 634.0 mg | 1268.0 mg (5 × 250mg) | 1902.0 mg | Every 8 hours |
| 80 lbs (36.3 kg) | 726.0 mg (3 × 250mg) | 1452.0 mg (6 × 250mg) | 2178.0 mg | Every 8 hours |
| 90 lbs (40.8 kg) | 816.0 mg | 1632.0 mg | 2448.0 mg (10 × 250mg) | Every 8 hours |
| 100 lbs (45.4 kg) | 908.0 mg | 1816.0 mg | 2724.0 mg (11 × 250mg) | Every 8 hours |
| 120 lbs (54.4 kg) | 1088.0 mg | 2176.0 mg | 3264.0 mg (13 × 250mg) | Every 8 hours |
| 150 lbs (68 kg) | 1360.0 mg | 2720.0 mg (11 × 250mg) | 4080.0 mg | Every 8 hours |
Parenthetical tablet amounts are arithmetic comparisons only. They do not account for scoring, release type, concentration, product labeling, or whether this medication is appropriate for an individual animal.
By Weight
Keppra reference by dog weight
Choose a common weight to open its optional reference page. Use the main medication calculator for a different exact weight.
Common-weight pages are convenience views of the same educational reference, not separate medical recommendations.
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How to Give Levetiracetam to Your Dog
Give levetiracetam tablets by mouth every 8 hours with food. Consistent timing is critical — set alarms to maintain even blood levels. Immediate-release tablets can be split if needed for accurate dosing. NEVER split or crush extended-release (XR) tablets. If a dose is missed, give it as soon as you remember and adjust the next dose timing. Do not double dose. Keep a seizure diary to help your vet assess treatment effectiveness. Never stop this medication abruptly.
It is generally recommended to give Levetiracetam with food to help reduce stomach upset. It may interact with Phenobarbital (may increase levetiracetam clearance, requiring higher doses), Other anticonvulsants, and Generally fewer drug interactions than phenobarbital or potassium bromide.
Side Effects and Safety
Common side effects include Sedation, Decreased appetite, Drooling, and Ataxia (wobbly gait). More serious side effects can occur, such as Severe sedation, Behavioral changes (aggression or anxiety), Hepatotoxicity (rare), and Pancytopenia (rare).
Cautions · 12
When Keppra should be used with caution or avoided
Some dogs should not take Keppra, or need a different dose and closer monitoring. Tell your veterinarian about your pet's full health history and every other medication or supplement they take before giving Keppra.
- Known hypersensitivity to levetiracetam
- Severe kidney disease (dose adjustment needed)
- Do not abruptly discontinue — taper gradually
Interactions · 13
Keppra drug interactions
Keppra can interact with other drugs. This list is not complete — always give your veterinarian a full list of your dog's medications and supplements.
Calculator Limits · 14
When not to use this calculator
This calculator gives a general educational estimate for a healthy adult dog at a known weight. Do not rely on it in these situations — talk to your veterinarian instead:
- In an emergency, or after accidental ingestion or a suspected overdose
- For pregnant or nursing pets
- For very young or very old dogs
- For pets with liver disease, kidney disease, or another chronic illness
- For pets taking several medications at once
- When you are not sure of your dog's current, accurate weight
- For combination products that contain additional active ingredients
Overdose · 15
Suspected overdose: what to do
If you think your dog had too much Keppra, or swallowed any medication by accident, act right away. Do not wait for symptoms to appear.
- Call your veterinarian or the nearest emergency animal hospital.
- ASPCA Animal Poison Control Center: (888) 426-4435
- Pet Poison Helpline: (855) 764-7661
A consultation fee may apply to the poison hotlines. Have the medication packaging ready, and note how much your pet may have taken and when. Do not try to make your pet vomit unless a veterinarian tells you to.
When to Call the Vet
If your dog experiences any of the following, contact your veterinarian or an emergency clinic immediately:
- Seizure lasting more than 5 minutes
- Multiple seizures within 24 hours (cluster seizures)
- Severe sedation where your dog cannot stand or eat
- Behavioral changes such as unusual aggression or extreme anxiety
- Yellowing of gums or eyes (possible liver issue)
Frequently Asked Questions
Frequently Asked · 07
Questions about this medication
Why is levetiracetam often preferred over phenobarbital?
Why does levetiracetam need to be given three times a day?
Can I suddenly stop giving levetiracetam?
Can levetiracetam be used alongside other seizure medications?
What should I do if my dog has a seizure while on levetiracetam?
Use This Guide Safely · 08
What weight alone cannot tell you
The calculator performs one narrow job: it multiplies your dog's weight by the lower, standard, and upper mg/kg values recorded for Keppra. It cannot decide whether this drug, indication, formulation, or schedule is appropriate for an individual animal.
Context in this medication record
- Commonly listed uses
- Epilepsy, Seizure management, Cluster seizures, Status epilepticus (emergency), Add-on seizure therapy
- Recorded forms
- Tablet, Extended-release tablet, Oral solution, Injectable
- Reference timing
- Every 8 hours; onset 1-2 hours; duration 8 hours (immediate release)
Individual checks a calculator cannot perform
- Confirm the diagnosis and the reason this medication is being considered.
- Match the exact product, concentration, route, and whether a tablet may be split.
- Account for age, pregnancy, organ function, genetics, allergies, and prior reactions.
- Review every prescription, over-the-counter product, and supplement your pet takes.
Recorded cautions
Known hypersensitivity to levetiracetam; Severe kidney disease (dose adjustment needed); Do not abruptly discontinue — taper gradually.
Recorded interactions
Phenobarbital (may increase levetiracetam clearance, requiring higher doses); Other anticonvulsants; Generally fewer drug interactions than phenobarbital or potassium bromide.
These lists reproduce the structured record used by this page and may not be exhaustive. Show your veterinarian the product label and your dog's complete medication list before acting on a number.
Related · 08
Related medications for dogs
Sources · 09
Sources & references
The structured medication record behind this page names the references below. The links open the publisher or official resource; they do not turn this page into a prescription for an individual animal.
- Plumb's Veterinary Drug Handbook — listed in this medication's source record.
- Merck Veterinary Manual — listed in this medication's source record.
- DailyMed label search for Levetiracetam — check current product and formulation labels; some veterinary uses may be off-label.
Source names are shown at the record level; passage-level page and label citations are still being added. Read our methodology and limitations.
Transparency · 11
How this page was made
This page's structured medication record includes Plumb's Veterinary Drug Handbook among its source names. PetDosageChart applies the record's mg/kg values to the entered weight and presents the arithmetic result. A source record is not the same as an individualized prescription or an independent clinical review.
- Sources cited
-
- Plumb's Veterinary Drug Handbook
- Merck Veterinary Manual
- Calculator formula
- Doses scale linearly from a standard basis of 40 mg per kg (18.14 mg per lb) of body weight, given Every 8 hours. The calculator multiplies that basis by your dog's weight and shows an arithmetic comparison with recorded tablet sizes. That comparison does not determine whether a tablet is scored, splittable, or appropriate for your pet.
- Editorial owner
- Prepared and maintained by the PetDosageChart editorial team, a software-led publisher and not a veterinary practice.
- DVM review status
- Not independently DVM-reviewed. A named reviewer and review date appear here only after a confirmed review.
More on our methodology and editorial process — how we source, calculate, and review dogs dosage data.
Safety · 10
More resources
- Pet Medication Safety Hub — What's safe, what's dangerous, and emergency signs
- How we calculate dosages — Our sources, math, and review process
- Printable emergency checklist — One-page reference for your fridge or first aid kit