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PetDosageChart

Isoxazoline antiparasitic · For Dogs · 100 lb

How much NexGard for a 100 lb dog?

A 100 lb dog (45.4 kg) should receive approximately 113.4 mg of NexGard per dose, given once monthly.

This dosage information is for educational purposes only. Always consult your veterinarian before giving any medication to your pet. Dosages may vary based on your pet's health conditions, other medications, and individual factors.

Content reviewed by licensed veterinarians. Sourced from Plumb's Veterinary Drug Handbook and the Merck Veterinary Manual.

Dosage · 100 lb dog

NexGard dose for a 100 lb dog

Low Dose

113.4

mg

Standard

113.4

mg

Max Safe

226.8

mg

Frequency

once monthly

Weight in kg

45.4 kg

Always confirm with your veterinarian before administering medication. These calculations are estimates based on published veterinary pharmacology references.

Other Weights

NexGard for a different size dog

FAQ · 100 lb dog

Questions about NexGard for a 100 lb dog

How much NexGard for a 100 lb dog?
A 100 lb dog should receive approximately 113.4 mg of NexGard (Afoxolaner) per dose, given once monthly. That works out to about 4 × 28.3 mg. Always confirm with your veterinarian before administering medication.
What is the safe dose range of NexGard for a 100 lb dog?
The published dose range for a 100 lb dog is roughly 113.4 mg (low) to 226.8 mg (max safe), with 113.4 mg as the typical standard dose. Frequency: once monthly.
How often can I give NexGard to a 100 lb dog?
NexGard is typically given once monthly. Do not exceed the recommended frequency without veterinary guidance.

Need a different weight?

Use the calculator on the main NexGard page for any exact weight, or read the full dosage chart and safety information.

Full NexGard dosage guide →

Sources · 09

Sources & references

The dosage information on this page is compiled from the following veterinary and pharmaceutical references:

  • Plumb's Veterinary Drug Handbook — the standard veterinary pharmacology reference used by veterinarians worldwide.
  • Merck Veterinary Manual — a trusted, peer-reviewed resource for veterinary professionals and pet owners.
  • DailyMed (FDA Drug Labels) — official FDA-approved drug labeling and prescribing information for Afoxolaner.

Read more about our methodology and how we calculate dosages.