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PetDosageChart

Prilosec (Omeprazole) Dosage for Dogs

Proton pump inhibitor ⏱ Onset: 1-2 hours; full acid suppression in 3-5 days ⏳ Duration: 24 hours per dose

This dosage information is for educational purposes only. Always consult your veterinarian before giving any medication to your pet. Dosages may vary based on your pet's health conditions, other medications, and individual factors.

Content reviewed by licensed veterinarians. This information is sourced from veterinary drug references including Plumb's Veterinary Drug Handbook and the Merck Veterinary Manual.

Dosage Calculator

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Prilosec Dosage Chart for Dogs by Weight

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Weight Low Dose Standard Dose Max Dose Frequency
5 lbs (2.3 kg) 1mg 2.5mg 3.5mg Once or twice daily
10 lbs (4.5 kg) 2.5mg 4.5mg 7mg Once or twice daily
15 lbs (6.8 kg) 3.5mg 7mg 10mg (10mg tablet) Once or twice daily
20 lbs (9.1 kg) 4.5mg 9mg (10mg tablet) 13.5mg Once or twice daily
25 lbs (11.3 kg) 5.5mg 11.5mg (10mg tablet) 17mg Once or twice daily
30 lbs (13.6 kg) 7mg 13.5mg 20.5mg (2 × 10mg) Once or twice daily
40 lbs (18.1 kg) 9mg (10mg tablet) 18mg (2 × 10mg) 27mg Once or twice daily
50 lbs (22.7 kg) 11.5mg (10mg tablet) 22.5mg 34mg Once or twice daily
60 lbs (27.2 kg) 13.5mg 27mg 41mg (4 × 10mg) Once or twice daily
70 lbs (31.7 kg) 16mg 31.5mg (3 × 10mg) 47.5mg (5 × 10mg) Once or twice daily
80 lbs (36.3 kg) 18mg (2 × 10mg) 36.5mg 54.5mg Once or twice daily
90 lbs (40.8 kg) 20.5mg (2 × 10mg) 41mg (4 × 10mg) 61mg (6 × 10mg) Once or twice daily
100 lbs (45.4 kg) 22.5mg 45.5mg 68mg (7 × 10mg) Once or twice daily
120 lbs (54.4 kg) 27mg 54.5mg 81.5mg (8 × 10mg) Once or twice daily
150 lbs (68 kg) 34mg 68mg (7 × 10mg) 102mg (10 × 10mg) Once or twice daily

What is Prilosec (Omeprazole) used for in dogs?

Stomach ulcers Gastroesophageal acid reflux Esophagitis NSAID-induced gastric erosion Helicobacter gastritis

How to give Prilosec to your dog

Give omeprazole by mouth on an empty stomach, 30-60 minutes before feeding. Do not crush or break enteric-coated tablets or open capsules, as the coating protects the drug from stomach acid. If your dog needs a smaller dose, ask your vet about compounded formulations. Administer at the same time each day for best results.

Available Forms

Tablet, Capsule, Oral paste

Give with Food?

No — can be given without food

Side effects of Prilosec in dogs

Common side effects

Diarrhea
Decreased appetite
Mild nausea
Gas or flatulence

Serious side effects

  • Vitamin B12 deficiency with prolonged use
  • Rebound acid hypersecretion on abrupt discontinuation
  • Hypomagnesemia with long-term use
  • Increased risk of GI infections

When to call the vet

Call your vet immediately if your dog shows any of these signs:

  • Vomiting blood or dark coffee-ground-like material
  • Black, tarry stools indicating GI bleeding
  • Persistent vomiting despite medication
  • Complete loss of appetite lasting more than 2 days
  • Weakness, pale gums, or signs of dehydration

Related Medications for Dogs

ACE inhibitor (angiotensin-converting enzyme inhibitor)

Vasotec

Enalapril

For Congestive heart failure

View dosage chart
Serotonin antagonist and reuptake inhibitor (SARI)

Desyrel

Trazodone

For anxiety

View dosage chart
Janus kinase (JAK) inhibitor

Apoquel

Oclacitinib

For atopic dermatitis

View dosage chart
Selective serotonin reuptake inhibitor (SSRI)

Prozac

Fluoxetine

For Separation anxiety

View dosage chart

Sources & References

The dosage information on this page is compiled from the following veterinary and pharmaceutical references:

  • Plumb's Veterinary Drug Handbook — the standard veterinary pharmacology reference used by veterinarians worldwide.
  • Merck Veterinary Manual — a trusted, peer-reviewed resource for veterinary professionals and pet owners.
  • DailyMed (FDA Drug Labels) — official FDA-approved drug labeling and prescribing information for Omeprazole.

Frequently Asked Questions

Should omeprazole be given on an empty stomach to dogs?
Yes, omeprazole is most effective when given on an empty stomach, ideally 30-60 minutes before the first meal of the day. This allows the drug to be absorbed and begin blocking acid pumps before food stimulates acid production.
How long can a dog take omeprazole?
Omeprazole is typically prescribed for 2-8 weeks depending on the condition. Long-term use beyond 8 weeks should be under close veterinary supervision due to potential nutrient absorption issues. Your vet may taper the dose rather than stopping abruptly to avoid rebound acid secretion.
Can I give my dog human omeprazole?
Many veterinarians prescribe human OTC omeprazole for dogs at appropriate doses. However, do not use formulations containing additional active ingredients (like combination heartburn products). Always confirm the appropriate dose with your veterinarian.
What are signs of stomach ulcers in dogs?
Signs include vomiting (sometimes with blood), dark tarry stools, loss of appetite, weight loss, abdominal pain, and lethargy. If you notice any of these, especially dark stools or bloody vomit, seek veterinary care immediately as ulcers can be serious.
Can omeprazole be used alongside NSAIDs in dogs?
Yes, omeprazole is commonly used as a gastroprotectant alongside NSAID therapy to help prevent NSAID-induced stomach ulcers and gastric erosion. This combination is particularly recommended for dogs on long-term NSAID use or those with a history of GI sensitivity.

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