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PetDosageChart

Antiparasitic combination · For Dogs · 10 lb

How much Trifexis for a 10 lb dog?

A 10 lb dog (4.5 kg) should receive approximately 136.1 mg of Trifexis per dose, given once monthly.

This dosage information is for educational purposes only. Always consult your veterinarian before giving any medication to your pet. Dosages may vary based on your pet's health conditions, other medications, and individual factors.

Content reviewed by licensed veterinarians. Sourced from Plumb's Veterinary Drug Handbook and the Merck Veterinary Manual.

Dosage · 10 lb dog

Trifexis dose for a 10 lb dog

Low Dose

136.1

mg

Standard

136.1

mg

Max Safe

272.1

mg

Frequency

once monthly

Weight in kg

4.5 kg

Always confirm with your veterinarian before administering medication. These calculations are estimates based on published veterinary pharmacology references.

Other Weights

Trifexis for a different size dog

FAQ · 10 lb dog

Questions about Trifexis for a 10 lb dog

How much Trifexis for a 10 lb dog?
A 10 lb dog should receive approximately 136.1 mg of Trifexis (Spinosad / Milbemycin Oxime) per dose, given once monthly. That works out to about 0.5 × 270 mg. Always confirm with your veterinarian before administering medication.
What is the safe dose range of Trifexis for a 10 lb dog?
The published dose range for a 10 lb dog is roughly 136.1 mg (low) to 272.1 mg (max safe), with 136.1 mg as the typical standard dose. Frequency: once monthly.
How often can I give Trifexis to a 10 lb dog?
Trifexis is typically given once monthly. Do not exceed the recommended frequency without veterinary guidance.

Need a different weight?

Use the calculator on the main Trifexis page for any exact weight, or read the full dosage chart and safety information.

Full Trifexis dosage guide →

Sources · 09

Sources & references

The dosage information on this page is compiled from the following veterinary and pharmaceutical references:

  • Plumb's Veterinary Drug Handbook — the standard veterinary pharmacology reference used by veterinarians worldwide.
  • Merck Veterinary Manual — a trusted, peer-reviewed resource for veterinary professionals and pet owners.
  • DailyMed (FDA Drug Labels) — official FDA-approved drug labeling and prescribing information for Spinosad / Milbemycin Oxime.

Read more about our methodology and how we calculate dosages.