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Isoxazoline antiparasitic · For Dogs

Credelio dosage reference for dogs (Lotilaner)

This page's standard weight-based reference is 30 mg per kg (13.61 mg per lb), with Once monthly recorded as the reference frequency. Use the calculator to see the arithmetic for your dog's weight, then confirm the indication, product, and actual dose with a veterinarian.

Onset
4 hours (fleas), 8 hours (ticks)
Duration
30 days
Class
Isoxazoline antiparasitic

Weight-based calculator estimate from the references listed on this page. This page has not been independently DVM-reviewed — see our methodology .

This information is for educational purposes only. Always consult your veterinarian before giving medication to your pet. Do not use this calculator for emergencies, overdoses, pregnancy, very young animals, very old animals, pets with liver/kidney disease, or pets taking multiple medications.

Each medication page lists the references recorded for its data. The calculator math and editorial presentation are maintained by PetDosageChart; a page is independently DVM-reviewed only when a named reviewer byline appears. See our methodology and limitations.

Lotilaner (often known by brand names such as Credelio) is an isoxazoline antiparasitic commonly used in veterinary medicine for Flea treatment and prevention and Tick treatment and prevention (including Lone Star, Black-legged, American Dog, and Brown Dog ticks). Understanding the correct dosage, administration, and potential side effects of Lotilaner is critical for your dog’s safety and well-being.

A typical Lotilaner dose for dogs is around 30 mg/kg Once monthly, within a usual range of 20-43 mg/kg. Available forms include Chewable tablet.

Calculator Warning: Use this only as an educational estimate. Your veterinarian may prescribe a different dose based on your pet’s condition, age, weight, other medications, and medical history.

Lotilaner Dosage Calculator for Dogs

Enter your dog’s weight below to estimate the Lotilaner dose from the 30 mg/kg guideline. Your veterinarian may adjust it for your dog’s age, condition, and other medications, so treat the result as an educational starting point, not a prescription.

Dosage Calculator · 01

Enter your dog's weight

Quick Dosage Chart

Typical Lotilaner amounts for common dog weights, for quick reference:

Dosage Chart · 02

Credelio weight-based reference chart for dogs

Scroll sideways to see full table

Weight Lower Reference Standard Reference Upper Reference Frequency
5 lbs (2.3 kg) 46.0 mg (56.25mg tablet) 69.0 mg (56.25mg tablet) 98.9 mg (2 × 56.25mg) Once monthly
10 lbs (4.5 kg) 90.0 mg 135.0 mg 193.5 mg Once monthly
15 lbs (6.8 kg) 136.0 mg 204.0 mg 292.4 mg (5 × 56.25mg) Once monthly
20 lbs (9.1 kg) 182.0 mg (3 × 56.25mg) 273.0 mg (5 × 56.25mg) 391.3 mg (7 × 56.25mg) Once monthly
25 lbs (11.3 kg) 226.0 mg (4 × 56.25mg) 339.0 mg (6 × 56.25mg) 485.9 mg Once monthly
30 lbs (13.6 kg) 272.0 mg (5 × 56.25mg) 408.0 mg 584.8 mg Once monthly
40 lbs (18.1 kg) 362.0 mg 543.0 mg 778.3 mg (14 × 56.25mg) Once monthly
50 lbs (22.7 kg) 454.0 mg (8 × 56.25mg) 681.0 mg (12 × 56.25mg) 976.1 mg Once monthly
60 lbs (27.2 kg) 544.0 mg 816.0 mg 1169.6 mg (21 × 56.25mg) Once monthly
70 lbs (31.7 kg) 634.0 mg 951.0 mg (17 × 56.25mg) 1363.1 mg (24 × 56.25mg) Once monthly
80 lbs (36.3 kg) 726.0 mg (13 × 56.25mg) 1089.0 mg 1560.9 mg Once monthly
90 lbs (40.8 kg) 816.0 mg 1224.0 mg (22 × 56.25mg) 1754.4 mg (31 × 56.25mg) Once monthly
100 lbs (45.4 kg) 908.0 mg (16 × 56.25mg) 1362.0 mg (24 × 56.25mg) 1952.2 mg Once monthly
120 lbs (54.4 kg) 1088.0 mg 1632.0 mg (29 × 56.25mg) 2339.2 mg Once monthly
150 lbs (68 kg) 1360.0 mg (24 × 56.25mg) 2040.0 mg 2924.0 mg (52 × 56.25mg) Once monthly

Parenthetical tablet amounts are arithmetic comparisons only. They do not account for scoring, release type, concentration, product labeling, or whether this medication is appropriate for an individual animal.

By Weight

Credelio reference by dog weight

Choose a common weight to open its optional reference page. Use the main medication calculator for a different exact weight.

Common-weight pages are convenience views of the same educational reference, not separate medical recommendations.

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How to Give Lotilaner to Your Dog

Give the Credelio chewable tablet by mouth once monthly with a full meal — food is essential for proper absorption. Choose the correct tablet size based on your dog’s weight. Most dogs accept the flavored chewable willingly. If refused, hide in a high-value treat like cheese or meat. Ensure the entire tablet is consumed. Give on the same date each month for consistent protection. Start treatment before flea and tick season begins for best results.

It is generally recommended to give Lotilaner with food to help reduce stomach upset. It may interact with Generally safe with most medications, Use caution combining with other isoxazolines, and Can be given alongside heartworm preventives.

Side Effects and Safety

Common side effects include Vomiting, Diarrhea, Decreased appetite, and Lethargy. More serious side effects can occur, such as Seizures (rare, class warning for isoxazolines), Tremors, Ataxia (incoordination), and Severe allergic reaction.

Cautions · 12

When Credelio should be used with caution or avoided

Some dogs should not take Credelio, or need a different dose and closer monitoring. Tell your veterinarian about your pet's full health history and every other medication or supplement they take before giving Credelio.

  • Dogs with a history of seizures or epilepsy (use with caution)
  • Puppies under 8 weeks of age or under 4.4 pounds
  • Known hypersensitivity to lotilaner or isoxazolines

Interactions · 13

Credelio drug interactions

Credelio can interact with other drugs. This list is not complete — always give your veterinarian a full list of your dog's medications and supplements.

Generally safe with most medications
Use caution combining with other isoxazolines
Can be given alongside heartworm preventives

Calculator Limits · 14

When not to use this calculator

This calculator gives a general educational estimate for a healthy adult dog at a known weight. Do not rely on it in these situations — talk to your veterinarian instead:

  • In an emergency, or after accidental ingestion or a suspected overdose
  • For pregnant or nursing pets
  • For very young or very old dogs
  • For pets with liver disease, kidney disease, or another chronic illness
  • For pets taking several medications at once
  • When you are not sure of your dog's current, accurate weight
  • For combination products that contain additional active ingredients

Overdose · 15

Suspected overdose: what to do

If you think your dog had too much Credelio, or swallowed any medication by accident, act right away. Do not wait for symptoms to appear.

  • Call your veterinarian or the nearest emergency animal hospital.
  • ASPCA Animal Poison Control Center: (888) 426-4435
  • Pet Poison Helpline: (855) 764-7661

A consultation fee may apply to the poison hotlines. Have the medication packaging ready, and note how much your pet may have taken and when. Do not try to make your pet vomit unless a veterinarian tells you to.

When to Call the Vet

If your dog experiences any of the following, contact your veterinarian or an emergency clinic immediately:

Frequently Asked Questions

Frequently Asked · 07

Questions about this medication

How does Credelio compare to NexGard and Simparica?
Credelio, NexGard, and Simparica are all isoxazoline-class flea and tick preventives. They share a similar mechanism of action and safety profile. Credelio (lotilaner) starts killing fleas within 4 hours, which is comparable to the others. The main differences are in palatability, specific tick species coverage, and individual dog response.
Why must Credelio be given with food?
Credelio requires administration with food for proper absorption. Studies show that giving Credelio with a meal significantly increases bioavailability, ensuring the drug reaches effective blood levels. Without food, the medication may not provide full flea and tick protection for the entire month.
Is Credelio safe for dogs with seizures?
The FDA has issued a class-wide warning for all isoxazoline products regarding potential neurological adverse events including seizures, tremors, and ataxia. Dogs with a history of seizures should use isoxazolines with caution and under close veterinary supervision. Alternative flea/tick preventives may be recommended for seizure-prone dogs.
Does Credelio protect against heartworm?
No, Credelio only protects against fleas and ticks. You will need a separate heartworm preventive such as Heartgard, Sentinel, or Interceptor. Some vets may recommend Credelio Plus, which combines lotilaner with milbemycin oxime for combined flea, tick, and heartworm protection.
What should I do if my dog spits out the Credelio tablet?
If your dog refuses the tablet, try wrapping it in a small piece of cheese, meat, or a pill pocket. The tablet must be given with food for proper absorption. If your dog consistently refuses it, talk to your vet about alternative flea/tick preventives that may come in topical or other forms.

Use This Guide Safely · 08

What weight alone cannot tell you

The calculator performs one narrow job: it multiplies your dog's weight by the lower, standard, and upper mg/kg values recorded for Credelio. It cannot decide whether this drug, indication, formulation, or schedule is appropriate for an individual animal.

Context in this medication record

Commonly listed uses
Flea treatment and prevention, Tick treatment and prevention (including Lone Star, Black-legged, American Dog, and Brown Dog ticks)
Recorded forms
Chewable tablet
Reference timing
Once monthly; onset 4 hours (fleas), 8 hours (ticks); duration 30 days

Individual checks a calculator cannot perform

  • Confirm the diagnosis and the reason this medication is being considered.
  • Match the exact product, concentration, route, and whether a tablet may be split.
  • Account for age, pregnancy, organ function, genetics, allergies, and prior reactions.
  • Review every prescription, over-the-counter product, and supplement your pet takes.

Recorded cautions

Dogs with a history of seizures or epilepsy (use with caution); Puppies under 8 weeks of age or under 4.4 pounds; Known hypersensitivity to lotilaner or isoxazolines.

Recorded interactions

Generally safe with most medications; Use caution combining with other isoxazolines; Can be given alongside heartworm preventives.

These lists reproduce the structured record used by this page and may not be exhaustive. Show your veterinarian the product label and your dog's complete medication list before acting on a number.

Related · 08

Related medications for dogs

Sources · 09

Sources & references

The structured medication record behind this page names the references below. The links open the publisher or official resource; they do not turn this page into a prescription for an individual animal.

Source names are shown at the record level; passage-level page and label citations are still being added. Read our methodology and limitations.

Transparency · 11

How this page was made

This page's structured medication record includes Plumb's Veterinary Drug Handbook among its source names. PetDosageChart applies the record's mg/kg values to the entered weight and presents the arithmetic result. A source record is not the same as an individualized prescription or an independent clinical review.

Sources cited
  • Plumb's Veterinary Drug Handbook
  • Merck Veterinary Manual
Calculator formula
Doses scale linearly from a standard basis of 30 mg per kg (13.61 mg per lb) of body weight, given Once monthly. The calculator multiplies that basis by your dog's weight and shows an arithmetic comparison with recorded tablet sizes. That comparison does not determine whether a tablet is scored, splittable, or appropriate for your pet.
Editorial owner
Prepared and maintained by the PetDosageChart editorial team, a software-led publisher and not a veterinary practice.
DVM review status
Not independently DVM-reviewed. A named reviewer and review date appear here only after a confirmed review.

More on our methodology and editorial process — how we source, calculate, and review dogs dosage data.

Safety · 10

More resources