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Monoclonal antibody (anti-IL-31) · For Dogs

Cytopoint dosage reference for dogs (Lokivetmab)

This page's standard weight-based reference is 1 mg per kg (0.45 mg per lb), with Once monthly (injection by veterinarian) recorded as the reference frequency. Use the calculator to see the arithmetic for your dog's weight, then confirm the indication, product, and actual dose with a veterinarian.

Onset
1-3 days
Duration
4-8 weeks
Class
Monoclonal antibody (anti-IL-31)

Weight-based calculator estimate from the references listed on this page. This page has not been independently DVM-reviewed — see our methodology .

This information is for educational purposes only. Always consult your veterinarian before giving medication to your pet. Do not use this calculator for emergencies, overdoses, pregnancy, very young animals, very old animals, pets with liver/kidney disease, or pets taking multiple medications.

Each medication page lists the references recorded for its data. The calculator math and editorial presentation are maintained by PetDosageChart; a page is independently DVM-reviewed only when a named reviewer byline appears. See our methodology and limitations.

Lokivetmab (often known by brand names such as Cytopoint) is a monoclonal antibody (anti-IL-31) commonly used in veterinary medicine for Allergic dermatitis, Atopic dermatitis, Chronic itching, and Environmental allergies. Understanding the correct dosage, administration, and potential side effects of Lokivetmab is critical for your dog’s safety and well-being.

A typical Lokivetmab dose for dogs is around 1 mg/kg Once monthly (injection by veterinarian). Available forms include Injectable.

Calculator Warning: Use this only as an educational estimate. Your veterinarian may prescribe a different dose based on your pet’s condition, age, weight, other medications, and medical history.

Lokivetmab Dosage Calculator for Dogs

Enter your dog’s weight below to estimate the Lokivetmab dose from the 1 mg/kg guideline. Your veterinarian may adjust it for your dog’s age, condition, and other medications, so treat the result as an educational starting point, not a prescription.

Dosage Calculator · 01

Enter your dog's weight

Quick Dosage Chart

Typical Lokivetmab amounts for common dog weights, for quick reference:

Dosage Chart · 02

Cytopoint weight-based reference chart for dogs

Scroll sideways to see full table

Weight Lower Reference Standard Reference Upper Reference Frequency
5 lbs (2.3 kg) 2.3 mg 2.3 mg 2.3 mg Once monthly (injection by veterinarian)
10 lbs (4.5 kg) 4.5 mg 4.5 mg 4.5 mg Once monthly (injection by veterinarian)
15 lbs (6.8 kg) 6.8 mg 6.8 mg 6.8 mg Once monthly (injection by veterinarian)
20 lbs (9.1 kg) 9.1 mg 9.1 mg 9.1 mg Once monthly (injection by veterinarian)
25 lbs (11.3 kg) 11.3 mg 11.3 mg 11.3 mg Once monthly (injection by veterinarian)
30 lbs (13.6 kg) 13.6 mg 13.6 mg 13.6 mg Once monthly (injection by veterinarian)
40 lbs (18.1 kg) 18.1 mg 18.1 mg 18.1 mg Once monthly (injection by veterinarian)
50 lbs (22.7 kg) 22.7 mg 22.7 mg 22.7 mg Once monthly (injection by veterinarian)
60 lbs (27.2 kg) 27.2 mg 27.2 mg 27.2 mg Once monthly (injection by veterinarian)
70 lbs (31.7 kg) 31.7 mg 31.7 mg 31.7 mg Once monthly (injection by veterinarian)
80 lbs (36.3 kg) 36.3 mg 36.3 mg 36.3 mg Once monthly (injection by veterinarian)
90 lbs (40.8 kg) 40.8 mg 40.8 mg 40.8 mg Once monthly (injection by veterinarian)
100 lbs (45.4 kg) 45.4 mg 45.4 mg 45.4 mg Once monthly (injection by veterinarian)
120 lbs (54.4 kg) 54.4 mg 54.4 mg 54.4 mg Once monthly (injection by veterinarian)
150 lbs (68 kg) 68.0 mg 68.0 mg 68.0 mg Once monthly (injection by veterinarian)

Parenthetical tablet amounts are arithmetic comparisons only. They do not account for scoring, release type, concentration, product labeling, or whether this medication is appropriate for an individual animal.

By Weight

Cytopoint reference by dog weight

Choose a common weight to open its optional reference page. Use the main medication calculator for a different exact weight.

Common-weight pages are convenience views of the same educational reference, not separate medical recommendations.

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How to Give Lokivetmab to Your Dog

Cytopoint is administered as a subcutaneous injection by your veterinarian only. It cannot be given at home. The injection is based on your dog’s body weight and is typically well-tolerated with minimal discomfort. Schedule monthly vet visits for ongoing treatment. No special preparation is needed before the appointment. Your dog can eat and exercise normally before and after the injection.

It may interact with Generally very few drug interactions and Can be used alongside most medications including Apoquel, steroids, and antibiotics.

Side Effects and Safety

Common side effects include Injection site reactions, Lethargy (transient), Mild vomiting, and Decreased appetite (temporary). More serious side effects can occur, such as Anaphylactic reaction (very rare), Facial swelling, Severe lethargy, and Recurring infections due to immune modulation.

Cautions · 12

When Cytopoint should be used with caution or avoided

Some dogs should not take Cytopoint, or need a different dose and closer monitoring. Tell your veterinarian about your pet's full health history and every other medication or supplement they take before giving Cytopoint.

  • Known hypersensitivity to lokivetmab
  • Active serious infections

Interactions · 13

Cytopoint drug interactions

Cytopoint can interact with other drugs. This list is not complete — always give your veterinarian a full list of your dog's medications and supplements.

Generally very few drug interactions
Can be used alongside most medications including Apoquel, steroids, and antibiotics

Calculator Limits · 14

When not to use this calculator

This calculator gives a general educational estimate for a healthy adult dog at a known weight. Do not rely on it in these situations — talk to your veterinarian instead:

  • In an emergency, or after accidental ingestion or a suspected overdose
  • For pregnant or nursing pets
  • For very young or very old dogs
  • For pets with liver disease, kidney disease, or another chronic illness
  • For pets taking several medications at once
  • When you are not sure of your dog's current, accurate weight
  • For combination products that contain additional active ingredients

Overdose · 15

Suspected overdose: what to do

If you think your dog had too much Cytopoint, or swallowed any medication by accident, act right away. Do not wait for symptoms to appear.

  • Call your veterinarian or the nearest emergency animal hospital.
  • ASPCA Animal Poison Control Center: (888) 426-4435
  • Pet Poison Helpline: (855) 764-7661

A consultation fee may apply to the poison hotlines. Have the medication packaging ready, and note how much your pet may have taken and when. Do not try to make your pet vomit unless a veterinarian tells you to.

When to Call the Vet

If your dog experiences any of the following, contact your veterinarian or an emergency clinic immediately:

Frequently Asked Questions

Frequently Asked · 07

Questions about this medication

How does Cytopoint work differently from Apoquel?
Cytopoint is a monoclonal antibody that specifically targets and neutralizes IL-31, the key itch-signaling cytokine. Unlike Apoquel (a JAK inhibitor that broadly suppresses immune pathways), Cytopoint works like a targeted missile against itch signals without broadly suppressing the immune system. This gives it a very favorable safety profile.
How quickly does Cytopoint start working?
Most dogs experience significant itch relief within 1-3 days of the injection. Some owners report improvement within 24 hours. The effect typically lasts 4-8 weeks, with most dogs needing monthly injections.
Can Cytopoint be used long-term?
Yes, Cytopoint has an excellent long-term safety profile. Since it is a targeted antibody rather than a broad immunosuppressant, it does not carry the same risks as long-term steroid or Apoquel use. Many dogs receive monthly injections for years with continued efficacy.
Can my dog get Cytopoint at home?
No, Cytopoint must be administered as a subcutaneous injection by a veterinarian. It is not available for home administration. You will need to schedule monthly vet visits or align injections with other routine appointments.
What if Cytopoint doesn't seem to last a full month?
Some dogs metabolize the antibody faster and may need injections every 4-6 weeks rather than every 8 weeks. Discuss with your vet if the effects wear off early — they may adjust the schedule or combine Cytopoint with other therapies for better control.

Use This Guide Safely · 08

What weight alone cannot tell you

The calculator performs one narrow job: it multiplies your dog's weight by the lower, standard, and upper mg/kg values recorded for Cytopoint. It cannot decide whether this drug, indication, formulation, or schedule is appropriate for an individual animal.

Context in this medication record

Commonly listed uses
Allergic dermatitis, Atopic dermatitis, Chronic itching, Environmental allergies
Recorded forms
Injectable
Reference timing
Once monthly (injection by veterinarian); onset 1-3 days; duration 4-8 weeks

Individual checks a calculator cannot perform

  • Confirm the diagnosis and the reason this medication is being considered.
  • Match the exact product, concentration, route, and whether a tablet may be split.
  • Account for age, pregnancy, organ function, genetics, allergies, and prior reactions.
  • Review every prescription, over-the-counter product, and supplement your pet takes.

Recorded cautions

Known hypersensitivity to lokivetmab; Active serious infections.

Recorded interactions

Generally very few drug interactions; Can be used alongside most medications including Apoquel, steroids, and antibiotics.

These lists reproduce the structured record used by this page and may not be exhaustive. Show your veterinarian the product label and your dog's complete medication list before acting on a number.

Related · 08

Related medications for dogs

Sources · 09

Sources & references

The structured medication record behind this page names the references below. The links open the publisher or official resource; they do not turn this page into a prescription for an individual animal.

Source names are shown at the record level; passage-level page and label citations are still being added. Read our methodology and limitations.

Transparency · 11

How this page was made

This page's structured medication record includes Plumb's Veterinary Drug Handbook among its source names. PetDosageChart applies the record's mg/kg values to the entered weight and presents the arithmetic result. A source record is not the same as an individualized prescription or an independent clinical review.

Sources cited
  • Plumb's Veterinary Drug Handbook
  • Merck Veterinary Manual
Calculator formula
Doses scale linearly from a standard basis of 1 mg per kg (0.45 mg per lb) of body weight, given Once monthly (injection by veterinarian). The calculator multiplies that basis by your dog's weight and shows an arithmetic comparison with recorded tablet sizes. That comparison does not determine whether a tablet is scored, splittable, or appropriate for your pet.
Editorial owner
Prepared and maintained by the PetDosageChart editorial team, a software-led publisher and not a veterinary practice.
DVM review status
Not independently DVM-reviewed. A named reviewer and review date appear here only after a confirmed review.

More on our methodology and editorial process — how we source, calculate, and review dogs dosage data.

Safety · 10

More resources